My opinon is that, they are much more likely to be guilty than innocent.
But the process has been botched entirely. It has brought doubt into the case. I don't know about the Italian system, but in the UK and USA, a verdict beyond all reasonable doubt must be made. Hence the furore.
The conditions under which some key evidence was retrieved for example, could have caused contamination. This doesn't mean it was contaminated, but nevertheless its a possibility.
The way Knox supposedly conducted herself, by pointing at an innocent man for example, is highly suspect. Not something you can quantify in court though.
Apparently the sentence will be reduced in appeals, which supposedly is "normal". Also will probably welcomed home like a hero after the sentence. Something a murderer shouldn't receive considering she will still have most of her life left.