Posted by WordlySandwich7 over at Reddit, link above.
I have this monitor too and was a little weirded out by the subpixel ordering. However, after looking into things I discovered that the 40" 4K monitor I have been using for the last 4 years also had BGR subpixels and I never noticed.
After reading the tftcentral and techspot in depth reviews, I landed on some solid settings for 120Hz 4K 8-bit SDR (personally don't care about HDR).
First off, set scaling to 100% in Windows. Remove/delete any color calibrations you have. Also delete the ClearType registry keys that exist in Computer\HKEY_CURRENT_USER\Software\Microsoft\Avalon.Graphics\DISPLAY*, leave only the (Default) (value not set) one.
On the screen OSD: GameVisual: User Mode Color: Brightness 60, Contrast 70, Saturation 50, Color Temp (User Mode, R: 100, G: 96, B: 100), Gamma: 2.2 Image: OD Level 4, ASCR Off, Adaptive-Sync On, Blue Light Filter Level 0, Dynamic Dimming Off, Shadow Boost Level 1.
This gives nice colors and very clear text without any software tweaks.
For me, the most important setting is actually Shadow Boost. You'll notice if you view the grey row of this image used for testing chroma subsampling, something weird happens with Shadow Boost Level 0;
http://www.avsforum.com/attachments/9759 (make sure you view this in vanilla Paint with no scaling). It appears like the grey pixels, although all the same value, have some local dimming occuring? Setting Shadow Boost to Level 1 virtually elimates this, which I think contributes to the text quality.
Personally, for that added touch, I've ordered a ARCTIC Z1 Pro (Gen 3) arm to mount the display so I can flip it 180 degrees for RGB ordering. I tested this manually and it definitely improves text sharpness another step (i.e., the OS doesn't care that I've set the display to be rotated, it assumes RGB ordering either way).