Early thoughts in no particular order:
I've played for a few hours now starting with a new game. Gameplay wise it feels easier than before, even on very hard enemies are very susceptible to being hacked to death. Though getting shot is way worse for my netrunner build. I can easily lose a huge amount of health with one hit. Realistic so no complaints, its just something I'll have to adjust to and which makes the scarcity of meds really impactful. Cant craft my own yet (if that's even possible in game now, still low level and limited to Watson).
Money doesnt seem to be an issue. So I'm disassembling looted guns for crafting mats
Driving is better but still not great on a K & M setup. Vehicle sounds are way better. Bikes might need tweaking they don't like turning or stopping
A number of the changes are very obviously influenced from popular mods. eg drawing a gun by holding down the B key (keyboard) uses the first time equipped animation.
One issue I've got is that the game feels sluggish. FPS (50 -70 normal for me) and frametimes (12 - 20ms) numbers are fine yet it just feels slow to react. FG is not enabled so that's not an issue.
Graphical glitches with RT are there but not common but when they do pop up they can be very obvious like flickering objects, very bright lights which shouldn't be there. The subtle ones I don't notice most of the time unless I'm looking for them.
I bought C2077 a few months ago and really loved it especially with a lot of mods installed. QoL, graphic upgrades and some to make the game harder like Enemies of Night City. 2.0 is good but maybe not as good as the early reviews made out. Hopefully we will get some patches to address the more obvious issues like the police response being way overtuned and spawning on top of you.