It will load up everytime you boot up your PC and be active on all desktop stuff. But like i said before some games will ignore it when running via exclusive full screen like 'The Division' so you just run them in borderless window mode instead, most others though run fine with the profile in exclusive fullscreen. The only issue would be if a game has no fullscreen borderless mode and ignores the profile in exclusive full screen mode but their can't be many games like that now in this day and age. I have an ICC profile running but it's my own as i have the equipment to calibrate myself and so don't need to use someone elses ICC profile like the one from TFT central. So in answer yes it will fix the gamma in all but a very few circumstances although the profile is not for your monitor but theres so it won't be as accurate on your version of the monitor but should be an improvement.
I think I'm gonna go with this then. Someone also mentioned using colour profile keeper and colour sustainer, are you aware of these programmes? Sorry for the rapid fire questions, been a long time since a bought a monitor so learning all this on the fly.
http://goebish.free.fr/cpk/
http://www.guru3d.com/files-details/color-sustainer-download.html
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