Soldato
You can thats what MSE is for, see the wiki article I linked too.
If, IF you were using MSE to test jpeg compression then your argument would be valid. But you arent, you're using it to test the rendering quality of FSR and DLSS against native and ignoring that lossy compression affects the image quality of the saved screenshots used to do the comparison. It's an uncontrolled variable therefor it's an invalid test.