Yeah tried that, DPI, fonts, GPU scaling @ custom res, monitor scaling in the end I had to DSR the monitor & gave up.
Those issues gave me severe headaches on many websites as pdf's & or certain website designs garbled the fonts it was very uncomfortable to look at for long due to the lack of clarity in the image. Could not find a way to get around it as it seemed to me like the Win 7 Clear Type tuner has a few dead zone gaps which meant it could not scale certain fonts properly.
The handful of games which have native 21:9 support looked stunning however. Such a shame I had to DSR as the image aside from the fonts was very good. Colours/contrast especially.
Still think 21:9 are stunning displays but the scaling issues are there on the Asus 21:9 not everyone notices them on Win 7 as most websites are ok. Perhaps on Win 8.1 they are fixed?