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good suggestion but orbitalwalsh's desk is an Ikea one, which I would be cautious coz the boards are not solid wood.@orbitalwalsh - ditch the case and make the cubby hole the actual case:
You could have an RGB modded front - i'm sure your wife would love that idea.
Some inspiration for you - imagine it's the cubby hole of your desk:
A hole here and there may weaken the structure significantly.