The E6300 has a multiplier of 7 and a 266 MHz FSB (quad pumped to 1066). The E4300 has a multiplier of 9 and a 200 MHz FSB (quad pumped to 800). What this means to the enthusiast is that the E4300 will reach a higher overclock without having to push the RAM too hard because most overclocking is accomplished by increasing the FSB.
For instance if I decided I wanted to run at 3.22 GHz and I had a E6300, I'd have to run a 460 MHz FSB. To do the same on an E4300 would need just a 360 MHz FSB.
The E6300 will get you a higher overclock at its limits but it will take good memory.
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