You'd still want to get rid of the hot air, so fans would still be preferred for the airflow. Looking at the Cooler Master promo picture front fan is blocked because of the power cables from the GPU and rear fan is blocked because of the termination. I thought this would be lower, but I guess the cards are wider than I thought. That means you really would only have the bottom radiator with its fans and nothing else. Might want to put a REALLY fat radiator then
All depends on space though, Alphacool NexXxoS XT45 would probably then only fit with thin fans, so may as well have a 30mm thick with 25mm fans. Doubt a Alphacool NexXxoS UT60 would fit
CM are using the rad fans for exhaust, which is probably the only way to do this. Always the option of putting slim fans between the top mesh and the frame though (discussed over past couple of pages). Could likely fit a full size fan in the front if 180 degree power adapters are used.