I started again but if you know the story (or just watch a recap on YouTube) then you might be best pressing on if you've already completed the first couple of chapters more than once.
I considered waiting for a next gen patch but that's going to be a while off, if it ever comes at all, Rockstar seem all in on GTA at the moment.
I'd like 4k60 obviously but that's all a next gen patch will provide, it won't change the game and for me I didn't want to wait indefinitely, especially as it still looks fantastic anyway.
My other main reason for starting over was I wanted version 1.0 so I could try out some of the glitches such as the infinite gold in the lock box in Limpany. Not having to worry about money is very liberating.