Soldato
I've been playing on my old save lately, on a low difficulty setting because I don't want my base to burn. Very fun and relaxing. With 300 mods no less. Let me big up some the good ones.
Couple of interesting mods in your list which I'll give a try in future. I'm currently running around 150mods (though to be honest some of them I don't even use even when I have them loaded).
Lately I've been playing with Combat Extended which changes the gameplay significantly, especially in commitment mode.
I use pretty much all of your QoL mods. Some of my "must have" mods are Use Your Gun, We Had a Trader, Toggle harvest, Room Food which works great with Rimfridge, Trade ship drop spot and Trading spot, Show Draftees Weapon, Smart Speed, Better Pawn Control, Mend and Recycle, Set up camp (great for Ice Sheet/ Extreme Desert bases to be able to go on hunting trips), Dubs Mint Menus, Rim HUD, Animals Logic, Research Pal, Simple Sidearms, Quality Builder, Wall Light and the best mod of them all Prepare Carefully (though lot of self discipline required when starting new game ).