The 600 has peak in the upper mid range the 650's are fairly flat through there. HD600 is bright in comparison also. Tone is different, HD650 has a wooden character, smoother, can handle busy cues without problem while the 600 blends them in comparison. 600 is leaner, grainier a bit more treble clarity due to its rise but it isn't as refined.
Both are great headphones and both are different.
Both are great headphones and both are different.