CPU: E6600 @ 3.7ghz
RAM: 4GB PC6400
Mobo: Abit AWD9-Max
GPU: ATI 1GB 4870
OS: Win7 x64
I get the same issues and all I can say is just save frequently, and after every save, do a second save under a different filename (save as) just incase your primary save goes down. Remember if the game CTD's during a save - that save file is corrupted and your work lost for good.
Tbh the game should autosave every x amount of days, it is a poor mechanism in place and it doesn't help that saving takes so long, so it breaks the flow of the game totally. Lastly, to those who aren't getting crashes, are you using any custom content from the exchange store? I have a feeling that could be the cause because I am....