If it helps this is what I use. I've learned from these forums and some AMD peeps on Reddit about what is best to have enabled and not enabled at the same time. So for me I use at a global level:
Radeon Anti-Lag = Enabled
(keep the CPU and GPU working together to reduce latency)
Radeon Boost = Enabled 33%
(dynamically reduce res for fast pace mouse motion in certain games)
Radeon Image Sharpening = Enabled 80%
(sharpening algorithm to restore in-game clarity)
Radeon Enhanced Sync = Enabled
(tear free experience reduce lag)
Wait for Vertical Refresh = Always On
(To limit FPS working along side FreeSync)
AMD FreeSync Premium = Enabled
(monitor specific)
Apparently you don't use FRTC (Frame Rate Target Control) with Enhanced Sync/VSync, as the algorithms aren't designed to work together, just stick with VSync to limit the framerates. So in this case mine is capped at 165FPS / 165Hz which I'll never hit unless playing a very old game, in which case VSync limits the FPS for me.
With this I've been playing games just fine. No lag issues, or screen tearing or pacing issues.
But everyone will have their own preference.