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Don't understand this new software crap. Play game fine no issues, then close it down Radeon Software doesn't opened like this screenshot.
Clean and fresh install all default settings.
Have to restart whole computer for it too load up.
post a picture
Task manager > Details Tab > right click Radeon Settings > End Task > Relaunch Radeon Settings.
I found it may be tied in to the explorer process. I have seen it behave like that myself as @Kevin Matthews shows if the driver has restarted.
The driver crashed while playing a game, you must have an unstable overclock or something. I had this for a while with my Vega 56, dropped some clocks and it went away.
Game was fine for me too, didnt even get a notification. Only noticed the driver crashed when icon vanishes from taskbar when hovering cursor over it or Radeon Settings came up like you see it.
Anyway run the AMDCleanupUtility.exe in the Bin folder found in the driver folder and reinstall.
I'll make more of an effort benchmarking drivers from now on, honest! 
Borderlands 3 saw an 8fps boost!I'll make more of an effort benchmarking drivers from now on, honest!
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But why as 19.12.3 is out @Aztec2Step ?
I'd be interested to hear how you find 19.12.3 behaves with BL3. On a like for like basis with same settings and overclock comparing 12.3 against 12.1, I found it to drop the benchmark frame rate by 7 fps without using DDU to uninstall 12.1 and by 3.5 fps when using DDU.


. Radeon Boost hasnt sneaked itself on by default or anything? Are you using a Wattman OC profile or predefined settings? I'm stumped why my frame rate tanks so much
. Perhaps these drivers are optimised better for Polaris than Vega?Good news but now I'm more confused. Radeon Boost hasnt sneaked itself on by default or anything? Are you using a Wattman OC profile or predefined settings? I'm stumped why my frame rate tanks so much
. Perhaps these drivers are optimised better for Polaris than Vega?
I checked Radeon settings prior to launching the game to ensure none of the settings had changed, specifically all the new voodoo being on by default lol. I use MSI Afterburner for overclocking as I didn't get on with Wattman when it first came out and see no reason to start using it.