What system have you moved from Robert? The X58 chipset has features in common with 775 and AM2+.
Uncore frequency needs to be set to your memory frequency x2, or (memory x2)+1 depending on who you ask. Mine is at 3200 for 1600mhz ram. Any lower and it will crash, any higher than 4000 and stability will become very hard to find.
As standard, setting memory to the lowest multiplier (x6) helps ensure that this isn't the unstable part while you focus on the cpu. Loosening the timings may help but is probably not needed, cas8 to cas9 say. Ram voltage set to 1.66V regardless.
Beyond that everything ties to bsck. Moving from 133 to 180 was quite a jump, I'm not surprised it wasn't stable. Moving in steps of 10 (200mhz ish), and raising vcore/qpi voltage as needed is a good compromise. Note that increasing either will increase temperatures, and stability will suffer as it runs hotter. It may well be "fine" at 90 degrees, but it'll need a hell of a lot more voltage for stability than it would do at 60. Hence more voltage isn't always better here, keep both of these as low as you possibly can before moving up a notch.
Turbo mode is a kind of enforced energy saving mode. If on, you get x21 multiplier but it'll throttle back to x20 under load if the bios lets it. With it off you get at most x20 available, hence me running at 200x20.
Load line calibration was introduced with P45 as a result of the enthusiast community bleating about vdroop. Vdroop is meant to happen, expected to happen, and specified to happen by Intel. I can rant about this at length, however I shall leave it with the comment that it provides zero benefit at the cost of motherboard stress and cpu voltage spikes.
You did ask for a template. Vcore 1.25V, qpi 1.3V, vdimm 1.66V, ucore 3200, qpi frequency the lowest available. 200 bsck, 1600mhz cas8 ram. Stable under anything I throw at it except higher ambients at which point the board gives up without a fan pointed at it. Processor hits 60 degrees.
Cheers