Well, I'm admitting defeat.
Been trying to figure out what was causing the pump in the CPU loop to be so noisy. Ended up swapping in another known good pump which did exactly the same thing. I've just checked the pump speeds and both pumps are within 50rpm of each other so it's not a pump speed issue, which leads me to believe it's just an inherent property of the DDC pump with high water flowrate.
I've taken the decision to retube it all as a single pump loop, looking at the performance graphs for the CPU block it's fairly flow rate independant.
Edit: Also the 8/10mm PVC tubing I have I'm not impressed with, once it gets warm it loses most of its strength.