All seem to work fine.
I know what you mean about CoD4 on the P35 tho, I tried Tri-Fire when the X2 came out with a 3870 and it was terrible.
Worked fine on single X2, but if you Tri-Fired the framerate just died.
Havn't had that problem with the 4850's, everything has just worked fine.
Though, when I look at the performance gains, probably a better option just to get the 4870....