*just thought I'd edit in here that this post contains spoilers if you're just getting started on the game. I'd put it in spoiler tags but the forum doesn't seem to support them.
so you've been warned
spoilers
anyway
Alright, I just completed the game, and the experience as a whole was absolutely superb. That said, it feels like, despite exploring as best I could, I left a lot of stones unturned?
Halfway through the game I find some big station thing, go inside, fiddle with some terminals and not having any co-ordinates to give to the computer, accidentally call in a nuclear strike on my own position. Wow, I think to myself, I must have chanced upon something that comes into play in the endgame! But wait, no, I go to Vault 87, then back to the Citadel, to the Jefferson Memorial, and suddenly you win game over gg. Oh. Well I wonder what the nuke tower was for? Also, I never found Dogmeat, which kind of sucks - I read some posts saying he's at a scrapyard or something, but I never found the scrapyard, wherever it was. And that's not for want of exploring, either, because I roamed the entire map freely for about 25 hours of game time, and hit the level cap long before I got anywhere near the end of the game. Another thing I've read a lot about was people finding Galaxy Radio, meeting Three Dog and interacting with / doing quests for him. Again, never happened to me. God knows where he was hiding. It'd be nice if NPCs actually mentioned the rough location (or at least existence!) of these places, so that the player could decide whether s/he wanted to spend the time to find them.
I know it's a nonlinear game and everything, but a little bit of handholding would have been cool. A lot of the most memorable parts of the game (for me) I wouldn't have experienced if dumb luck hadn't seen me blindly stumble upon them, and given that the first playthrough lasted 30+ hours, I don't think I'll have the patience to play through the game again to try and catch the things I missed the first time around, which is a shame.
Anyway, those are the only whinges I can come up with, and they mostly concern the game having too much content, which can't be bad! That aside, it was fantastic, and Bethesda have made me look like a chump for telling anyone who would listen for the past six months that F3 was going to suck. GOTY easily for me.