I should hope so, given your username!
I guess it depends how long you intend to keep the phone for. I've had this HTC desire for far too long... in future I'm going to look at changing phones at around 12-month intervals. In that timeframe, a single android upgrade should be plenty to keep a phone up to date, though I agree it can be annoying how long it takes the updates to filter through.
Regarding the Nexus "stock android" advantage: I can certainly see the benefit in most cases, but
occasionally the manufacturer builds can be useful as well. For example, with the Note2 I like the idea of the stylus-oriented features, and also the multi-tasking aspects of the TouchWiz build. Yes you need to balance this against the extra bloat, but with a powerful phone and plenty of memory / storage it shouldn't be too much of an issue.