When I use the Dram calc using the manual profile after importing my timmings, the settings even on safe are just way to fast for my system. Previous BIOS would blue screen, new BIOS just fails.
At least with V1 safe profile, it boots and it is somewhat stable. I had similar settings previously that eventually after a few weeks of stability froze. The only difference now is I have typed out ALL the timings and sub timings form the calc as well as added in all the power supply details as well which was something I have never done before.