With Zen 4 and 5 most of the problems start when you try to run 64gb+ kits. You can get CPU's with a real stinker Mem controller that just wont post with 64gb kits (and higher) or will actually post but won't accept EXPO / XMP profiles leaving you with JEDEC speed and timings.
64gb kits (and higher) are dual rank dimms, which further stress the memory controller and in the case of Zen 4 and 5 it's not great to start with.
48gb kits with Hynix M die IC's are generally safe as they are the highest capacity on single rank dimms.
Anyone buying new should check the Mem kits they are looking at have Hynix M or A die IC's for the least issues of compatibilty.
Thank you