In the past it has been stuff like providing single channel RAM set ups for APU based notebooks which rely heavily on RAM latency/speed/capacity. Several of the few recent ryzen ones that have came out have had poor cooling design that has significantly throttled the system between what should be spec identical laptops, giving worse performance than the mobile parts should provide and providing a inconsistant user experiance. You then also have the very poor driver support for the onboard graphics, provided by vendors who were the only source that provided drivers often several months behind, which despite AMD promising to solve, has not been integrated into every new driver release as far as i am aware. These are all well known issues.
I have a full desktop system with them. But the laptop output by themselves and their partners has been flawed and particularly lackluster. Hopefully this is the start of changes in this area. Those laptops seem decent, I look forward to the reviews. (price is £949 btw)
Well, their official position, very sadly and unfortunately, is:
https://techguided.com/single-channel-vs-dual-channel-vs-quad-channel/So, Should I Just Stick to Single Channel Memory Then?
The tests above show that, for gaming, there isn’t any kind of noticeable difference between running your memory in single and dual channel memory configurations.
This, of course, doesn’t mean that dual channel configurations shouldn’t be considered.
Not the best link but I cannot find right now one better.
Regarding the drivers - yes, AMD promised to begin releasing drivers on their own website this quarter.
Cooling I don't know. My Acer Nitro 5 with dual graphics including a discrete RX 560X runs fine.