To start off with, I just want to remind people that ArcheAge is partial loot PVP. The main slots in your inventory are safe(so is your money), but if you want to carry more loot, you need to bring backpacks or resource packs to carry heavy loads. The more load you carry the slower your walking speed gets (and your mount speed if your carrying a pack on a mount), and it is these items that can be looted from dead corpses.
Trade Runs
Trade Runs are essentially dailies that you need to do in order to get special coins called Delphi Coins. Delphi coins are used to buy blueprints. Houses, Boats, Castle segments, pretty much all crafted items and pets require Delphi coins.
When you talk to a Trade Run NPC, they will give you an item of goods, the item of goods will be too big and heavy to place in your inventory. So you will need to carry a resource pack on your back. Then the Trade Run NPC will instruct you to give that item to another NPC somewhere in the world.
If you want to build a boat, house, castle or even buy baby animals to train, then you will need to do these dailies to get Delphi coins.
The Journey
You will need to haul that item of goods to a NPC somewhere in the world. You can actually trade it to any Trade Run NPC, but the closer the NPCS are to the quest giver the less credit you get.
The ultimate Trade Run NPC's are on a small island in the middle of the northern ocean, so if you are able to trade the good to them you get the most coins. The trick is that all factions, and guilds use these same NPCs to turn in their packages. So most of these trade in spots are highly contested, and major wars break out between guilds to see who can control the flow of resources.
But the Journey is a dangerous one, because you have to carry a trade package, it can be looted by anyone. If anyone kills you and loots your corpse, they can turn it the package themselves, and they get the quest credit. If you die and get looted then you will have to go to another city where they have a Trade Run NPC and get the daily from there.
Pirates are red to all NPC's except for the guild npcs. So for a pirate to get the Delphi coins he needs, he is going to have to kill other players to get their loot, and turn it in to get the credit.