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I'm running a 660GTX, 8GB Ram, i5 2550 and SB Z. I've selected single screen performance in nVidia CP, and use optimal settings in GeForce Exp and it runs okay until I come across an enemy then it stutters, sometimes worse than others. Why I don't know. I read somewhere there is a patch being released on the 15th to address the issues. I haven't played SP yet.