My tips:
Open the game Properties in Steam & Set Launch Option to:
-limitfps 35
Anything between 35-45 works well and you will have nice cool/quiet graphics card while you play.
Keeping everything aligned and designing nice road patterns is tricky. I
strongly recommend the
Precision Engineering mod as it takes away a lot of the frustration.
At some point you will goof and have a one-way road pointing in wrong direction. Install
One-Way Street Arrows will make the mistakes easier to spot. There is a button to toggle it on/off on the roads menu.
You can use the Road Upgrade tool to flip the direction of One-Way roads so you don't have to replace them if you make a mistake.
Installing *any* mod disables Steam Achievement. Install
this mod to turn them back on
To terminate the initial motorway connection. Use a 2-lane One-way road to make a roundabout about 20 units in diameter. This will allow you to disperse traffic in 3 directions and it will cope with all the traffic of the early game until you get the money to start putting in other motorway links.
Worth sticking to dirt roads until you get over the 1000 pop mark as they save a lot of money while you wait for everyone to move in and start paying their taxes
Apart from that just read the tool tips and popup tutorials and you should find it fairly easy going.