Must admit seeing this thread getting active again got me wanting to play it again; spent last weekend watching some YouTube videos again. Deleted all my old saves and started a new vanilla build. Got it up and running in a reasonable amount of time, still only the first block being used and stockpiling money before starting up the second and third zones. Keep wasting / splashing money trying to get an effective exit from the highway into the first zone too as there's a lot going on already. One big-ish roundabout worked for a long time until the lorries and such heading to my industrial zone started backing up an awful long way. Had a decent one-way system working for the entire industrial zone but it seems it started to bottleneck on the exit back to the roundabout. Such a great game, can waste hours and hours on this.
I'm actually going to try it on the lounge TV this weekend as my Steam Link arrived a week or two ago, that should be fun!