Walton Simons always gave me the willies. When you encountered him at the undersea base or wherever it was, I used to leg it as fast as I could. He couldn't climb up ladders.
He is a pretty tough boss type character in that context - its another thing I liked about that game though - they didn't block you from using "creative" ways to get around parts of the game - one time around I used the barrels and stuff in that bit to prevent him from being able to attack me directly.