You must have "golden ears" - honestly I've done a similar back to back comparison several times.
Most recently (2 weeks ago) I bought a cheap Class D amplifier to use with an old spare set of speakers, to use outside in the garden.
To test the amplifier, I used some left over ~2m offcuts of DCSk 16 AWG Pure Copper:
https://www.amazon.co.uk/gp/product/B00WG9BV4M
Happy with this, I then bought 30m of Amazon Basics 16 Gauge Speaker wire
https://www.amazon.co.uk/gp/product/B006LW0W5Y
Despite using this for 2x 15m runs, and it not even being pure copper (it's copper coated aluminium), it sounds EXACTLY the same.
It's funny you mention DCSK cable, as I run 4mm DCSK on my main system.
Previous I was using whatever cable Yamaha supplied with the speakers in the box (i'm using Yamaha floorstanding speakers). When I switched the 4mm it makes my speakers louder, again it was subtle but it was there, it also had a slight negative effect as it make the treble a little high.
On copper coated aluminium I've noticed difference in this compared to pure copper also, a few years ago I ordered some CCA cable by mistake. My view is the CCA has to be thicker to match the pure copper cable.
But the 16AWG cable it's to thin in my view, i'm curious what wattage speakers are you using this cable on?
Regarding golden ears, you can give me a collection of CD player, or collection of turn tables, and listen to them all, and I will pick out the best ones from the bunch.
Incidentally the best source I've heard was a Pioneer Pl-570 made in late 70's, those turntables sell for well over £1000, I stayed up night in my house listening to Beatles records on it, there is something very special about those old Pioneer high end record players. The sound is almost spiritual, it's like your picking up almost 40 years of whatever was in the record player. The record player had come from an old persons home.
I can tell you the difference between a Maxell chrome tape and a Sony metal tape, of course recorded on a good quality separates tape deck.
Going back to DCSK, this is the reason this thread started. I was going to buy some 2.5mm DCSK cable, however we come out of EU you can't buy it any more, so instead I just doubled up the thinner cable I already had, hence I posted the results on here. And I no longer need 2.5mm as the improvement from doubling is plenty, as it's saved buying better cable.