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Wow!!! You use a lot of memory
If you are going over the 8GB, it could be that which is causing the issues. Give msconfig a look and knock off a few processes from start up that are hogging resources.
Hi,
When it locks up does the screen go black?
That's what's been happening to me on similar(ish) MB and GPU.
Gigabyte Z77-DS3H Intel Z77 (Socket 1155) DDR3 Motherboard
Sapphire 7850
http://forums.overclockers.co.uk/showthread.php?t=18420510
Ah OK. Maybe try disabling audio completely to rule that out?
I don't know what caused my issues, drivers or power or something else. I'm going to hold back on an RMA and see if it happens again over the next few days.
Good luck with yours.