Keeping it plain and simple at work. E-mail on one desktop pair (two apps, different mail platforms for now), console and browser open on the first desktop pair, along with pidgin and a windows app I need running under wine, all with a little bit of compiz polish and awn.
Yes, I have two different sized monitors on my desk here.
Picture is of Nā Mokulua islands as viewed from Lanikai beach a short distance from where I live.