I think I have the worst luck ever on POF! It's crazy how many messages I've sent..I think about 30 without A SINGLE reply!..and that's pretty much all the girls that seem nice/interesting within 5/10 mile radius, so I think I'll have to give up on POF for now, pretty damn depressing..do only good looking guys get replies or something? I would love to know why I'm not getting any reply from any girl..I know I'm quite ugly but I'm a nice guy if that counts for anything these days..
It can seem depressing mate, I've sent around the same amount of messages as you, I got 4-5 replies that seemed only really to be replying out of kindness.
Yet I somehow managed 2 dates from okcupid, first one I didn't see any attraction yet the second one we're on for a 3rd date tommorow, but now I've actually found someone I like I've started to keep my appearances up, wear aftershave, new clothes and I've started to notice more girls flirting.
If you're having no luck online get out there and give some lucky gal a ticket to the gun show!
edit - Don't think of yourself as ugly mate, it does you no favours, I used to be really shy and think of myself that way until I started to think about how I come across to girls, gave myself a good slap in the face and started to do things to gain my confidence.