You are buying inot a system though, so a short term outlook is pointless. Ergonomics change a little between camera generations but there is a lot of consistency. For example I find Canon DSLR incredibly odd with dials going the wrong way, mount is backwards and much more limited UI with equal models to Nikon lacking top LCD or having only a single dial for aperture.
Anyway, the most importan thing is how well the F-mount adapter works. These are nearly always disappointing but the F-mount adapter Nikon made for the Nikon 1 series was one of the better ones. The issue comes doen to the short flange height and unique micro-lens array required, plus the completley different AF system can cause lots of issues.
I guess this is what you are used to. I think Nikon’s mount is the wrong way myself, it is not just wrong way to Canon or Sony or Fuji or Olympus, it is the wrong way to every other thing in the world that screws down to lock, like the twist lock on a tripod, the plate on the tripod, a bottle cap, screw thread, drills, wheel nut, etc etc. Clockwise direction to go down, anti-clockwise to unscrew and lift.
Nikon’s mount is the opposite of that so IMO that is the wrong way.
As for ergonomics, it is also what you are used to, like the exposure compensation, I know older Nikon cameras when you turn the dial clockwise the needle goes to the left…that’s backwards, I know you can flip that around now but it really shouldn’t be an option on this as many things in the world you start from the left and go to the right, like opening a book, reading a sentence, you start from the left and go to the right. Who decides that it was logical to move the left (to minus) when you turn it clockwise? Move to the left, less light, move to the right, more light. More = clockwise, like you are reading more in a sentence, left to right.
It’s what you are used to, I am used to Canon, I am sure I can get used to a Nikon too, even that silly backwards mount.
