Though corsair's icue has its own host of issues, it does have official plugins to control some Asus things through the one app; I control the light on my strix x570-f gaming through icue, and to my knowledge it can also control asus GPUs.
There's one called (iirc) Aurora which has some limited functionality, it's mostly for keyboards and mouse -
openRGB on the other hand looks like it can do many more things. I didn't test it out fully, no need to in my scenario, but I can confirm it worked with my corsair light strips. Unsure if it has per-game profile support but it's worth a look if your setup asks you to juggle programs and you don't want to.
To my knowledge that 10GB cap has only been hit with Watch Dogs Legion on max at 4K which - at least at launch - was a notoriously bad port and I don't think you can call that indicative of most games. Gearbox claimed Godfall would take 12GB VRAM at max settings on 4K, only for it to launch and people measure it as only demanding 8GB max.