There is a really good tips and tricks thread on reddit atm. Well worth a looky. I wont link it as there are more than a few swearies.
EDIT: Added some in
1.At your workbench press T to immediately dump all your junk into the container. That's triangle on ps4. The E button is X on ps4.
2.The laser musket can be charged twice, just hit reload again. The more charges, the more damage.
3.You can give your settlers specific jobs to do. Open the construction menu and find your settler, then assign them a task.
4.You can remove the mods on the weapons you find, instead of just dismantling them altogether.
5.Legendary weapons and armors are marked with a star. (I'm pretty sure, could be wrong).
6.At your weapons or armor bench you can tag the certain components you need with T. The appropriate items you find in the world will be marked with a magnifying glass. (Should be obvious but I overlooked it until recently.)
7.If you're against a corner and you aim down the sights you will peek around the wall. That's the new cover system.
8.Searchlights can be shot down.
9.Hold Down Shift to use WASD for Crafting and Dialogue options instead of the Arrow Keys for the PC Version.
10.You can turn sideways to squeeze through tight openings.
11.Hold down Q to enter VATS mode without enemies present. This allows you to view the VANS Quest Trail Perk so you can see the path to your next objective.
12.While using the missile launcher, you can shoot, start the reload, switch weapon and back and the thing is reloaded
13.If you are building yourself a house in the first town, don't pay attention to the old houses bases, instead, start by creating the floor, the walls will snap correctly and you will have correct dimensions. (I tried to follow the bases and it was pure frustration...)
14.This is a carry over from 3 and NV but when you're hacking, if there are open and close brackets of the same kind, hovering over the open one will highlight them both. Click on these to either remove a dud word or occasionally reset your number of tries.
15.tab and right click for a torch