Buttons as in hood buttons? If so, yes. I have the top buttons on my Di2 programmed to shift - right shifter is down (move right) and left is up (moves left) so easy to remember.
See it's things like that which I think would be the game changer for me. I feel when my gears are indexed well, the shifting is as fast as I would ever need it.
But being able to shift from the hoods would be a massive boon for pretty much everything.