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Hi Superpatsy I have exactly the same issue, so running without MSAA at the moment. No biggy, as I want 60fps and FXAA is enough for me at 1080p. I am also getting a few nasty stutters when driving but that is probably my 4gb system ram.
Win7 64, I5 2500k 4.2ghz, 4gb ram, R9 280X.
Make sure you have enough pagefile memory allotted since you don't have nearly enough ram. In game I'm hitting right about 7gb ram usage and it still attempts to use a decent amount of pagefile.
These open world games are like this. You gotta step your ram game up son!