And please people dont just rely on autosaves...
Look what happened to this guy

(From Official Fallout 3 Forums)
"So tonight as I was about 40+ hours into this game working on a certain quest in the Jefferson Memorial building, I go down into a hatch, the normal "autosaving..." message comes up as usual then all of a sudden the game freezes and decides to say [censored] you to my computer(first time its ever crashed on me). I have a pretty good computer(xp pro, 2.4 quad core, 4 gigs of ram and duel 8800gt) and I was forced to hit the reset button on my computer because I was unable to do ANYTHING. So Im thinking at least my game saved before it crashed...yeah, no. I go to the load screen, I see my autosave game there, try to load it and something really weird happens. It drops me right outside in front of vault 101 with no gear, map has been wiped clean of locations, no quest to do, and it like I have just walked out of the vault except worse because I have nothing, not even any clothes.
40+ hours of gaming COMPLETELY gone. I guess its partly my fault for relying on autosaving but this should never happen in any game. If theres any way to fix this let me know...otherwise I want my $60 back Bethesda basically stole from me."
http://www.bethsoft.com/bgsforums/index.php?showtopic=900039
All his fault the poor noob