Well, seems to have gone fine. Used ddu to get rid of amd stuff and installed 382.53. All seems to be fine, tested firestrike and played a lot of Rocket league, all seems to be behaving itself.
Not that I spend a lot of time in there, but I have to say unless I missed something, the Nvidia control panel looks a little barebones. I'm sure most of the functionality is in there, but it doesn't look much different from last time I had a system on Nvidia (7800GTX, used until it died). Not really sure what I was expecting, just seems really dated compared to Crimson control panel. The way people carry on, I just expected more than a white box with a list in it I guess.
Got Shadowplay installed, I like how everything gets it's own folder unlike relive which just dumps them all in one place. Seems much the same other than that.