In theory, it should be as simple as setting the strap to 400MHz, set the CPU Clock to Manual, and key in [400]. The 400MHz strap should set everything else required to run the CPU at 400MHz comfortably. Depending on your current CPU voltage, you might need to tweak it up a touch, and the RAM, if that doesn't run at 1.85V by default.
You can turn off speedstep, but with such a small overclock, you'll probably find you don't need to, unless your E6750 is especially volt-hungry.
If it sits inside the square box surrounding the CPU socket, then it will fit, and probably be quite a good choice with the horizontal loop cooler on the northbridge. The stock Intel fan is 80mm with another 1cm on each side for the lugs. I think it should fit fine.