Quoted in various review sites.
"Outside of the US, Samsung sells their phones with their own Exynos chips instead of Qualcomm Snapdragon. They also use Samsung made camera sensors, instead of the Sony ones in the US version. These parts are inferior, and there are numerous comparisons online. The Exynos phones are slower, have worse battery life, worse camera sensors and processing, get hotter and throttle faster, etc. This maybe wouldn’t be so bad if Samsung were transparent about it, or if we were’t paying the exact same price or even higher than our US friends."
So in summary,
Poor Battery life
Thermal throttling / overheating
Poor gpu performance compared to other flagships (sd865)
Poorer camera sensor
As stated by others in mundane day to day tasks probably not much of an issue, bar battery life. But i would say why buy a flagship if all you are going to do is open Facebook and WhatsApp etc.
Buy a decent midrange like pixel 4a or oneplus nord.
Previous generations the gap wasnt as noticeable, i loved my note 9 which was exynos 9810 and wish i hadn't swapped to a s20+. I get the issues mentioned, battery is awful, it overheats and it just isn't a good as the note 9 it replaced.
Its happening again with the note 20, but the gap will be bigger due to 865+ in other regions.
I'm loving the look of the mi 10 ultra, and would swap if it came to the UK. Which is looking doubtful, not sure about importing one.