CPPC along with the core scheduler in the OS should pick the best cores from CCD1 to use for workloads that only require a certain amount of cores, ie games. Most games will use 4-8 cores at most, so there is no need to start disabling cores to improve performance as for the most part it won't.
However, if you are using a 5950X/5900x, you may actually see a slightly higher average clock frequency on your CCD1 cores with CCD2 disabled, and this
might allow some extra performance due to the higher clock frequency for the prioritised cores. The extra clock frequency comes from the
slightly reduced power usage from having half the cores disabled.
If the game is using 6+ cores though with the 5900x, this might hurt performance more than help it as it has less cores to work with than the 5950X. Not tested it myself, just a theory and SMT might mean that its okay.
What I have tested though is this:
Here is my 5950X with 16 cores/32 threads
Here is my 5950X with CCD2 disabled, so running 8 cores/16 threads.
Note the difference in average frequency observed over time.
That was taken using COD Black Ops, 4K max settings on a 6900 XT. Other games may see different behaviour, so this may not apply to everything.