Yes, the differences can be enormous - on my overclocked E6300 I've got 34C mainboard temp and 35C CPU temp under load after 24 hours. PC Wizard reports the same two temperatures but also 66C and 68C for the two core temperatures. I would suspect that the 66C and 68C are the more realistic numbers. Still, as it won't throttle until at least 85C+ I'm not at all concerned.