Started playing friday and am up to 19 hours so far, lvl 14 and haven't even hit the vegas strip yet (am still in novac).
I'm having a great time exploring, always plenty to do be it side quests, exploring a mine, whatever i can see myself easily hitting the 60 - 80 hour makr on this first playthrough!
I've got difficulty set to normal and i'm playing in hardcore mode, i'm finding i have JUST enough ammo to get by aslong as i don't waste it (switching between a 9mm, a hunting rifle and the varmit rifle atm), food and water haven't been a problem so far, though my stocks of purified water are running low, and i'm constantly running out of stim packs!
Anyone who's exploring do yourself a favour, listen to all the dialogue, read all the computer entries, there're some true "O ****" moments out there that're really worth the time (vault 11 comes to mind for anyone who's been there) and some of the lore and background really helps set the scene and highlight exactly what people will do to survive.
I have noticed 1 thing though, i found a nice power fist (paladin toaster i believe) that causes huge amounts of damage, much more than my guns (i have 95 gun skill and 15 melee and the fist does 47 damage while my hunting rifle only does 27), can anyone tell me if this trend continues? i.e. untrained melee weapons out damaging my well trained guns?