Just been giving it a go sat at my desk using tabletop and split joycons in the octo expansion where there are bots. It's going to take some getting used to but yeah I think my brain can cope with the change. Not sure where to hold my right hand lol
I rest my forearms on my legs as all the motion is in the wrist, except when I panic and then move my arm too which results in pretty much no movement!
Split joycons work so much better than the Pro controller because instead of aiming by effectively using a steering wheel motion you are using the right joycon like a laser pointer which is so much more intuitive. Just make sure you always move at the wrist and not the elbow or shoulder.