Soldato
Programming and running virtual machines for work stuff. Playing the odd game for leisure times. I simulate networks using virtual machines so having 10 or more running at the same time isn't unheard of. The 5950 does look good but it is on dual channel RAM and has fewer PCIe lanes so I wouldn't be able to use as many NVMEe drives plus a GPU in 16x mode.
I'm doing... pretty much this and not seeing much issue to be honest. The last drive might well run in 2x nvme but it's a low tier one anyway. (500GB 970 evo plus, 2TB sabrent rocket, 1tb addlink).
Get a stooooopid fast boot drive, a decent main and a big 660p/some other QLC nvme drive for mass storage and you're golden.
I moved to a G6 external soundcard so I'm using no other lanes anywhere (only a single bulk 2TB "innovision" sata ssd on the ports that don't eat extra lanes) it's tight but it fits.