I had tons of issues over my usage of AM5, there have been many who have had memory training issues, bios options that haven't worked, features that have been buggy or not worked very well such as Nitro. Extremely long boot times, forced internal GPU being enabled despite being disabled in the BIOS, High Voltage Mode for memory not working correctly, USB dropout issues, PCIEX GPU speed issues under load, incorrect SOC voltages and reported voltages, far too high default voltages (Ryzen AMD cookoff issue) M2 detection issues, I could go on. Even Buildzoid pointed out many options that simply do not work in AM5 BIOS's for certain boards and manufacturers.
I personally did not encounter many of these but I did a few, especially the issues with HVM, GPU PCIEX speeds , and long training times, and this has nothing to do with the crap option of Memory Context Restore that actually increases your latency even if it is stable, when it often isn't.
Thankfully ASUS seem to be one of the better ones to address their BIOS, I mean they had to after Gaming Nexus heavily criticized ASUS and AMD at launch, but I had many of these issues and more when I had an MSI board but I guess was unlucky in the early adopter crowd.