After running through the game twice, once evil and once good, I had a third go through with the intention of making the uberest character possible (maxed stats, skills, and max possible damage output / damage resistance / accuracy from perks). This turned into basically the most completist run possible, the proceeds of which are posted here as a kind of catharsis in the hope that I can finally stop playing the game now (at least until the DLC comes out).
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S.P.E.C.I.A.L. attributes. I'm pretty sure this is the highest they can be got with all ranks of Intense Training and stat-boosting gear. Before anyone points it out, I know they're basically just cosmetic now unlike in F1/2. I just liked the idea of getting them as high as possible.
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Skills - with Comprehension and Educated, everything was 100 by the end of the game, except the two skills I literally never ever used (Explosives and Unarmed).
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Perks (mspaint lol). Every quest perk possible has been got (with the exception of Dream Crusher as it's mutually exclusive with Survival Guru). Where there were multiple possible benefits from a perk the combat-enhancing ones have been taken each time, so +3% crit from Moira and +5 DR from Harold. I've got (I think) every possible +damage output/resistance/accuracy level-up perk for projectile weapons (except Toughness which my End didn't allow for).
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Bobbleheads!
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The house, decked out in Science theme with all purchasable mod cons.
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Mmmm, Nuka-Cola (lol).
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The Locker of Win™, containing every unique weapon in the game, all legitimately found, including those that are supposedly mutually exclusive (Ant's Sting, Protectron's Gaze), those which you aren't supposed to be able to get (the awesome Colonel Autumn's Laser Pistol), and two of Eugene just for good measure. I also set myself the task of repairing them all to 100%, which was pretty difficult in some cases, and required some trickery with the Alien Blaster. (n.b. Colonel Autumn's Laser Pistol is actually in my inventory - for some reason it gets treated as a quest item, so you can't stash it).
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Bunch of unique armors. In the fridge, naturally.
Closing thoughts after what I fervently hope will be my last playthrough: after putting about 50 more hours into this game, it's gone up in my estimation from 'easily game of the year' to 'best game in recent memory'. It's baffling that after three complete runs through the game, having got the Explorer perk and looking at the world map, there are still a bunch of locations that I haven't visited even once. Also, despite trying out a bunch of different builds, everything is exceptionally well balanced, with a lot of different approaches viable and no one skill or perk being a gamebreaker.
The only thing that's a bit off kilter, that I found, is the awesome power of A3-21's Plasma Rifle coupled with how easy it is to get. There's nothing to stop a knowledgeable player from stepping out of the vault, picking up the Replicated Man quest in Megaton, then pretty much going straight to Rivet City, dodging a couple of Mirelurks and having Harkness hand you (imo) the best weapon in the game. The fact that you can also obtain the Wired Reflexes perk (+10% to hit in VATS) at the same time just makes it more overpowered, and if you tailor your early build around obtaining this gun (Energy Weapons / Sneak) then as soon as you get it, you will sail through the rest of the game killing almost everything in one shot. Still, I guess it's no more critical than the Power Armor in F1, and it says a lot that that's the only criticism I can think of.