I've been using XP 64 for about a week now and have found the following, my EOS300D doens't work with it, at all, not even in PTP mode and there are no drivers out yet, my scanner (Canon Lide 35) and thrustmaster wheel don't work either, compared to the original Windows XP it seems sluggish, there's a lot more disk access for some reason, it's certainly no faster that's for sure, WoW is a nightmare now in Ironforge, you sit around waiting for 10-20 seconds for stuff to load before you can move. I'm planning to go back to XP Pro as soon as I've got a chance to back stuff up.