They are settings that usually depends on memory quality. The more stable settings are higher voltage, and 2T (memory command rate). The XMP profile basically tells you what the manufacturer recommends for safe and stable operating values for particular memory sticks, and you should stick to those. If you still have problems, increase the command rate (2T), and increase the voltage a bit.
Higher volts means more stress on the component, but increase in stability (more signal to noise ratio, if you will).
Sandybridge memory controller prefers lower volts, so it's always good to push the volts down, ideally 1.55V, 1.5V.
All in all, it is best to stick to the recommended values, and then tweak them although the performance gains will be marginal. If you are having stability issues with XMP values, you can increase the vram voltage little by little (0.01V to 0.05V increments), and set the command rate to 2T if 1T is recommended. Do not exceed 1.65V.